Open PhD student &
Research Technician positions in
Cancer Microscopy & Mechanobiology
One research technician and one PhD student position are open until filled. Earliest starting date is September 1st, 2020. We are looking for independent and ambitious candidates for a project investigating the role of intrinsic (eg cell cycle) and extrinsic (interactions with extracellular matrix, fat, nerves) in invadopodia assembly and cancer cell invasion. Focus of this multidisciplinary study is on the integrative effect of complex microenvironment signals on tumor cell phenotypes and tumor cell decision-making. Project is heavily relying on 4D microscopy (multiphoton, confocal, intravital and others) and is using 3D culture models (spheroids, organoids, microfluidic chambers), as well as fluorescently labeled mouse models of breast cancer. Towards automated image segmentation and classification, we use machine learning and collaborate with other labs on computational modeling of invasion.
Candidates with BS/MS (for PhD student position) or with PhD (for postdoc position) in life science, with a strong background in one or more of the following: microscopy and image processing, mouse models of cancer, molecular & cell biology, quantitative biology, Matlab, microfluidics will be given preference. Salaries are based on F31/F32 NIH-guidelines.
Funding from NIH and ACS is secured for 4+ years https://grantome.com/grant/NIH/R01-CA230777-01A1
Applicants are expected to apply for student/postdoctoral fellowships. Ability to work as part of a team is fundamental.
Interested applicants should send their cover letter including research interests (1 page), CV and three reference letters (including one from PhD advisor) to email@example.com.
Philadelphia is home to a large biotech industry and vibrant, highly collaborative research environment which includes Penn, Drexel, Thomas Jefferson and Temple Universities among others. Temple University, a major urban research-intensive university in Philadelphia, PA with an excellent quality-of-life in terms of culture, recreation and sports, is an equal-opportunity/affirmative action employer. Applications from women and minorities are especially encouraged. Detailed information about the College of Engineering and its Departments can be obtained at http://www.temple.edu/engineering
1. Invadopodia-mediated degradation is enriched in the G1 phase of the cell cycle, J Cell Science (2019)
2. Contact guidance is cell cycle-dependent, APL Bioengineering (2018)
3. ECM Cross-Linking Regulates Invadopodia Dynamics, Biophysical Journal (2018)